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4 Ecological and applied perspectives Despite the growing body of research on MHB, our current understanding of their ecological roles, mechanisms of action, and evolutionary significance remains fragmentary

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Despite their importance, it should be noted that risk alleles are specific to certain drugs, in specific ethnicities, suggesting that their occurrence in the host is necessary, but not sufficient in itself to promote a complete immune response.11,19 One example of a pharmacogenomic study, where an HLA haplotype is associated with susceptibility to DRESS, is the association between the use of abacavir, in Antiretroviral Therapy (ART), and the increased risk of developing DRESS, if the patient is Caucasian or African-American and a carrier of HLA-B*5701

In cells under oxidative stress