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As seen with blood cells, a fast high-capacity binding, which was diminished by phloretin, was recorded, suggesting that this metabolite is actively distributed into endothelial cells as well

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In the adjuvant setting, the recommended regimen for patients with good functional status is mFOLFIRINOX (a modified form of FOLFIRINOX consisting of oxaliplatin, irinotecan, leucovorin, and 5-fluorouracil), whereas for those with suboptimal status, gemcitabine-based therapy (with capecitabine or as monotherapy) is standard [15]